Keeping up with COVID 19 (paper no. 2 )

Friday, 20 March, 2020

 

Full paper can be found here :

https://onlinelibrary.wiley.com/doi/10.1111/all.14238

 

 

 

Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China

Jin-jin Zhang

Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China

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Xiang Dong

Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China

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Yi-yuan Cao

Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China

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Ya-dong Yuan

Department of Respiratory and Critical Care Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China

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Yi-bin Yang

Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China

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You-qin Yan

Department of Infectious Disease, No. 7 Hospital of Wuhan, Wuhan, China

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Cezmi A. Akdis

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland

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Ya-dong Gao

Corresponding Author

E-mail address: gaoyadong@whu.edu.cn

Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China

Correspondence

Ya‐dong Gao, Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China.

Email: gaoyadong@whu.edu.cn

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First published: 19 February 2020
Citations: 6
Jin‐jin Zhang and Xiang Dong contributed equally to this work.
 
 

Abstract

Background

Coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS‐CoV‐2.

Methods

Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID‐19 patients, with confirmed result of SARS‐CoV‐2 viral infection, were extracted and analyzed.

Results

An approximately 1:1 ratio of male (50.7%) and female COVID‐19 patients was found, with an overall median age of 57.0 years. All patients were community‐acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self‐reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground‐glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r = .486, P < .001) and nonsevere (r = .469, P < .001) patients after hospital admission. Significantly higher levels of D‐dimer, C‐reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all P < .001).

Conclusion

Detailed clinical investigation of 140 hospitalized COVID‐19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS‐CoV‐2 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients.

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